A major emergency response was launched in Brisbane's south after a bus and truck collided on Mt Cotton Road in Carbrook, leaving the bus driver trapped inside the wreckage and several people requiring medical assistance.

Queensland emergency services were called to the scene shortly before midday on Thursday, with initial reports indicating that the bus had crashed into the rear of a truck travelling along the busy roadway.

Upon arrival, firefighters discovered the bus driver trapped in the heavily damaged vehicle. Multiple crews from the Queensland Fire Department worked urgently to free the driver using specialised rescue equipment.

Queensland Ambulance Service confirmed that the male bus driver sustained life-threatening injuries and was transported to Princess Alexandra Hospital in a critical condition following his extrication from the bus.

A female passenger aboard the bus also suffered serious injuries in the collision. Paramedics treated her at the scene before she was transported to the Royal Brisbane and Women's Hospital, where she was reported to be in a serious but stable condition.

The occupants of the truck involved in the crash escaped physical injury, although they were assessed by emergency personnel as a precaution.

Police established a traffic exclusion zone around the crash site while investigators examined the circumstances surrounding the collision. The incident caused significant disruptions along Mt Cotton Road, with motorists advised to avoid the area and expect lengthy delays as emergency crews remained at the scene.

Authorities have not yet released details regarding the number of passengers on board the bus at the time of the crash or the factors that may have contributed to the incident.

Forensic crash investigators are expected to conduct a detailed examination of the scene, including the position of the vehicles, road conditions and any available witness accounts. Investigators may also review dashcam footage from passing motorists to assist in determining exactly how the crash unfolded.

The incident serves as another reminder of the dangers faced by professional drivers and commuters on Queensland roads. Emergency responders praised the swift actions of those who contacted authorities and assisted in managing the situation until specialised rescue teams arrived.

Local residents described the emergency response as substantial, with numerous police vehicles, ambulances and fire appliances converging on the area within minutes of the crash being reported.

Queensland Police have urged anyone who witnessed the collision or who may possess relevant dashcam footage from Mt Cotton Road around 11.50am to contact investigators.

As inquiries continue, the focus remains on the recovery of those injured and providing support to everyone affected by the traumatic event.

Motorists travelling through the Carbrook region have been reminded to exercise caution, remain alert to changing traffic conditions and follow directions from emergency services personnel.

The investigation into the circumstances surrounding the crash remains ongoing.