Victoria has recorded eight road deaths during the Melbourne Cup long weekend following a series of serious crashes across metropolitan Melbourne and regional areas. Several other people have been injured, with some reported to be fighting for their lives in hospital.

One of the latest incidents occurred overnight at the intersection of South Road and Olive Street in Brighton East, south-east of Melbourne. A car and motorcycle collided, killing both the motorcycle rider and the driver of the car at the scene. A child travelling as a passenger in the car was taken to hospital with minor injuries.

Police are investigating the circumstances surrounding the collision. The identities of the two men had not been formally released at the time of the ABC report.

Another fatal motorcycle crash occurred in Blairgowrie on Saturday night. A 26-year-old man died after the motorcycle he was travelling on lost control and struck a tree. His passenger, a 29-year-old man, suffered life-threatening injuries and was taken to hospital.

In Maryborough, a collision involving two cars resulted in the death of one driver. His female passenger was taken to hospital with serious injuries. The driver of the second vehicle was not injured, while a teenage passenger sustained minor injuries.

A separate crash in Werribee also claimed a life after a utility vehicle lost control and struck a tree. The driver, who was the vehicle's only occupant, died at the scene.

Earlier on Saturday, a 75-year-old woman was fatally struck by a vehicle while crossing at a pedestrian crossing in Dennington, near Warrnambool. The driver stopped and provided assistance, but the woman died at the scene.

Another motorcyclist died following a collision with a car in Footscray. The car driver was interviewed by police and released while further enquiries continue. A separate fatal motorcycle crash was also reported in Healesville on Friday evening.

The incidents have renewed calls for motorists to take extra care during the busy Melbourne Cup period. Police have urged drivers to reduce speed, remain alert and take particular care on regional roads and longer journeys.

The Transport Accident Commission reported that 220 people had died on Victorian roads so far this year, according to the ABC report. Authorities are investigating the individual crashes and have appealed for witnesses and anyone with relevant CCTV or dashcam footage to come forward.

The weekend's fatalities highlight the serious consequences of road accidents and the importance of safe driving, especially during holiday periods when traffic volumes increase.