Several people, including children and teenagers, have been injured following a serious three-vehicle crash in Cabramatta, in Sydney’s south-west.

Emergency services were called to the Hume Highway near Longfield Street at about 11.15pm on Sunday, following a collision involving three vehicles. Police and emergency crews attended the scene, where multiple people required medical assessment and treatment.

The crash involved a BYD ute travelling eastbound, a Lexus SUV and a Mazda sedan. Initial reports indicate the BYD collided head-on with the Lexus, which then struck the Mazda.

The driver of the Lexus, a man aged in his 50s, suffered critical head injuries in the collision. Firefighters were required to free him from the vehicle before he was transported to Westmead Hospital for urgent medical treatment. His condition was described as critical.

Several children travelling in the BYD were also injured. An eight-year-old child suffered facial injuries, while two other children reportedly sustained injuries associated with their seatbelts. The children were taken to The Children's Hospital at Westmead for treatment.

The driver of the BYD was also treated at the scene before being taken to hospital.

People travelling in the third vehicle, a Mazda sedan, were also assessed following the collision. The vehicle's male driver, a female passenger and two teenage girls were taken to hospital as a precaution.

The incident resulted in a significant emergency response in the Cabramatta area, with firefighters, police and ambulance crews working at the scene.

Major road crashes involving multiple vehicles can require extensive emergency operations, particularly when people are trapped inside damaged vehicles. Firefighters may need to use specialist equipment to safely remove injured occupants while paramedics provide treatment.

Police crash investigators are now examining the circumstances surrounding the collision. Investigators will work to establish how the vehicles came together and determine whether any traffic or criminal offences may have occurred.

The investigation is expected to consider factors including the movements of the vehicles immediately before the crash and the conditions on the road at the time.

The incident highlights the serious consequences that can follow high-speed or head-on collisions on major Sydney roads. The Hume Highway is an important transport route through Sydney's south-west, carrying significant volumes of traffic each day.

As the investigation continues, police may appeal for witnesses or dashcam footage that could help establish what happened immediately before the crash.

The condition of the critically injured man remains a major concern, while the injured children and other passengers are receiving medical care.

This is a new Sydney-area breaking story reported today and is different from the Bankstown aviation story covered previously.