A major Queensland Police operation targeting the supply and distribution of cocaine in Fortitude Valley has resulted in 48 arrests and more than 90 criminal charges, marking one of the largest recent drug crackdowns in Brisbane's nightlife district.

The investigation, known as Operation Perico, was conducted by officers from the Fortitude Valley Tactical Crime Squad over four weekends during May after authorities received intelligence indicating that cocaine was being trafficked throughout the busy entertainment precinct.

Fortitude Valley, one of Brisbane's most popular nightlife destinations, attracts thousands of patrons each weekend. Police say the operation focused on identifying and disrupting established drug supply networks operating within and around the area.

As a result of the investigation, officers laid more than 90 charges against the 48 individuals arrested. The alleged offences include:

Trafficking dangerous drugs, Supplying dangerous drugs, Producing dangerous drugs, Possessing dangerous drugs, Possessing property suspected of being the proceeds of crime, and Weapons-related offences.

During the operation, police seized:

Approximately 169 grams of cocaine, Around $40,000 in cash, and A knife allegedly carried in a public place.

Authorities also released footage from the investigation showing officers uncovering concealed drugs, stacks of cash and cocaine hidden inside a disguised container designed to avoid detection.

Among those charged was a 22-year-old Logan Reserve man, who faces multiple allegations including trafficking dangerous drugs, supplying dangerous drugs, producing dangerous drugs and possessing property suspected of being linked to drug offences. He is scheduled to appear before the Brisbane Magistrates Court in July.

A separate 19-year-old Alderley man was charged with possessing a knife in a public place and was expected to face court proceedings this week.

Senior Sergeant Travers Weychardt, from the Fortitude Valley Tactical Crime Squad, said the operation had successfully disrupted an established supplier and removed a substantial quantity of illicit substances from Brisbane streets.

He emphasised that drug-related offending extends beyond private transactions and often contributes to broader community harm.

"These types of offences are never simply a private exchange between two people," he said.

"They impact the whole community, fuelling crime and endangering lives."

Police also warned that individuals involved in drug trafficking could expect significant legal consequences, including imprisonment.

The operation forms part of Queensland Police's ongoing strategy to reduce drug availability in areas with high concentrations of nightlife activity. Fortitude Valley has historically been identified as one of Brisbane's hotspots for drug detections due to its dense concentration of licensed venues and late-night entertainment.

Authorities are continuing investigations and have encouraged members of the public to provide information relating to illegal drug activity through Crime Stoppers.

The successful completion of Operation Perico demonstrates the increasing focus law enforcement agencies are placing on disrupting both street-level dealers and the broader networks that support illicit drug distribution.

Police believe the arrests have significantly weakened cocaine supply channels operating within the Valley and have reiterated their commitment to ensuring Brisbane's entertainment precinct remains safe for residents, workers and visitors alike.

As court proceedings continue, many of those charged will face allegations carrying substantial penalties under Queensland's drug laws.