A former Mount Gambier man has been jailed for at least two years and eight months after police intercepted him at Adelaide Central Bus Station while he was preparing to travel towards Mount Gambier with illicit drugs and a large amount of cash.

Jason Patzel, 44, who was born in Millicent and spent much of his life in Mount Gambier, pleaded guilty to drug-related offences in the District Court in Adelaide earlier this month.

The case followed a police operation in September last year after investigators received information that Patzel was allegedly carrying illicit drugs and was intending to board a bus travelling to Mount Gambier.

Police attended Adelaide Central Bus Station shortly before 8am and detained Patzel before he could board the bus. A search was conducted under South Australian drug legislation.

During the search, officers found a backpack containing multiple vacuum-sealed and press-sealed bags containing a white crystalline substance that police identified as appearing to be methamphetamine. Further quantities of the substance were allegedly concealed in other containers.

Police also located a bottle containing a clear liquid that appeared to be GHB, along with drug-related paraphernalia.

More than $40,000 in cash was also seized. Court evidence indicated that a large portion of the money was bundled together, adding to the seriousness of the offending considered by the court.

The prosecution case focused on the trafficking of methamphetamine and the potential harm associated with the distribution of illicit drugs. The court considered the quantity of drugs, how they had been packaged and the substantial amount of cash found in Patzel's possession when assessing the seriousness of the offending.

Judge Domenico Petraccaro also considered Patzel's personal circumstances and previous criminal activity during sentencing.

The court ultimately determined that the offending was too serious for the sentence to be served through home detention.

Patzel was sentenced to a period of imprisonment with a non-parole period of at least two years and eight months.

The case has a direct connection to Mount Gambier because Patzel had spent much of his life in the city and the drugs were allegedly being transported on a bus bound for Mount Gambier.

Authorities regularly warn that the trafficking and distribution of methamphetamine causes significant harm to individuals, families and communities. The case also demonstrates how investigations can extend beyond the location where drugs are ultimately intended to be distributed, with police intercepting suspected couriers before they reach their destination.

The sentencing follows the earlier seizure and investigation and provides a significant local court development for the Limestone Coast community.