Two teenagers have been arrested following a large factory fire in Tullamarine, in Melbourne's north-west, early Monday morning.

Emergency services were called to Flight Drive shortly after 3am on September 28 after reports of a building fire. Firefighters arrived to find smoke and flames coming from a large tilt-slab factory measuring approximately 30 metres by 30 metres.

Fire Rescue Victoria increased the emergency response after crews assessed the size of the blaze. Firefighters wearing breathing apparatus worked to contain the fire and prevent it from spreading to neighbouring properties. The fire was brought under control at approximately 4:36am.

There was nobody inside the factory when emergency services arrived and no injuries were reported. However, smoke from the fire led authorities to issue a community advice message for the surrounding area while firefighters worked at the scene.

The circumstances surrounding the blaze are now being investigated by Victoria Police after the fire was deemed suspicious.

Police later identified a vehicle of interest travelling at high speed in Meadow Heights. Officers followed the vehicle into Roxburgh Park, where it was abandoned on St Clair Boulevard and the occupants fled.

Police subsequently arrested two people, aged 16 and 18, on Sheridan Way. They are expected to be interviewed by detectives as the investigation continues. Police have not indicated that charges have been laid at this stage.

Investigators are continuing to examine the circumstances surrounding the fire, including the events before the blaze and the movements of the vehicle of interest. Further information may be released as the investigation progresses.

The incident caused a significant emergency response in Tullamarine during the early morning, with additional firefighting resources deployed because of the size of the factory and the potential risk to nearby properties.

Firefighters successfully prevented the blaze from spreading to adjoining buildings. Crews remained at the location after the fire was brought under control to extinguish remaining hotspots and ensure the site was safe.

Police are asking anyone who witnessed suspicious activity around Flight Drive or surrounding areas during the early hours of Monday morning, or anyone with relevant information or vision, to contact investigators.

The investigation remains ongoing, and the circumstances behind the suspicious factory fire have not yet been established.