A two-storey townhouse has been destroyed by fire in Mayfield, Newcastle, with an adjoining home also damaged during a major blaze on Monday night.

Emergency services were called to a property on Carrington Street at about 7pm on September 14 after multiple emergency calls were received reporting the fire. Firefighters from Fire and Rescue NSW's Lambton station responded to the incident alongside Newcastle police.

When emergency crews arrived, the townhouse was already fully alight. Firefighters worked to bring the blaze under control while also concentrating on preventing flames from spreading to nearby properties.

The townhouse was ultimately destroyed by the fire. An adjoining townhouse sustained damage, but firefighters were able to prevent the blaze from spreading further into neighbouring properties.

Police have established a crime scene at the property and are investigating the circumstances surrounding the fire.

A 42-year-old man attended the Carrington Street address at approximately 9.30pm and was detained by police. He was later taken to hospital for assessment. Police said there were no reported injuries resulting from the fire.

The investigation is now focused on determining how the fire started and what circumstances led to the property becoming fully engulfed.

The incident caused a significant emergency response in the Mayfield area, with firefighters working at the scene to extinguish the flames and protect surrounding homes.

While the townhouse could not be saved, the response helped limit the impact on neighbouring properties. Firefighters' efforts were particularly important given the close proximity of adjoining homes in the residential area.

Authorities have not released further details about the circumstances surrounding the fire while the investigation continues.

Fire and Rescue NSW has used the incident to remind residents about the importance of household fire safety. Residents are encouraged to make sure smoke alarms are working correctly and to ensure escape routes remain clear.

Firefighters also recommend keeping hallways, stairways and exits free from clutter so occupants can leave a property quickly if a fire occurs.

The Mayfield incident is a reminder of how quickly a residential fire can develop and threaten neighbouring properties, particularly where homes are located close together.

Residents are encouraged to check their household smoke alarms regularly and make sure everyone living in the home understands how to exit safely during an emergency.

Police will continue investigating the circumstances surrounding the Mayfield fire. At this stage, no injuries have been reported.