Human remains believed to belong to Nadire Sensoy, a Sydney woman who vanished more than seven years ago, have been discovered in Seven Hills, marking a significant development in one of New South Wales' most enduring missing person investigations.

Ms Sensoy, aged 71 at the time of her disappearance, was last seen near her home in Prospect, in Sydney's west, on December 6, 2018. Family members reported her missing five days later after becoming increasingly concerned about her welfare and the complete absence of activity on her bank accounts and personal records.

Following years of investigation, NSW Police launched multiple searches and offered a $350,000 reward for information relating to Ms Sensoy's suspected murder and the location of her remains.

On Thursday, detectives excavating an area along Powers Road in Seven Hills discovered human remains buried in a shallow grave approximately 100 metres from a creek bed. Police believe the remains are those of Ms Sensoy, although formal forensic identification is still underway.

NSW Police Superintendent Darrin Batchelor said the discovery brought mixed emotions for Ms Sensoy's family.

"They did get comfort that her body had been located," he said.

"But obviously the emotions of reliving what had happened to their mother. They were quite upset at the same time."

A 50-year-old man is already before the courts charged with domestic violence-related murder in connection with Ms Sensoy's disappearance. Police allege the woman was killed in the Blacktown area between December 6 and December 11, 2018.

Court proceedings relating to the case began after a coronial inquest into Ms Sensoy's disappearance was suspended in 2023, following the arrest of the accused. Authorities have indicated that additional charges may be considered once forensic examinations determine the precise cause of death.

Superintendent Batchelor praised investigators for their persistence over the years, noting that detectives had "never given up" on locating Ms Sensoy and providing answers for her loved ones.

The remains have now been transferred to the NSW Coroner, where specialists will conduct further examinations to confirm the identity and establish how Ms Sensoy died.

The case has once again highlighted the devastating impact of domestic violence-related homicides and the lengthy trauma endured by families awaiting answers about missing loved ones.

Although the discovery has reopened painful memories for Ms Sensoy's relatives, police say it may also provide a measure of closure after years of uncertainty.

Investigations remain ongoing, and the $350,000 reward for information connected to Ms Sensoy's death continues to be available. Detectives are urging anyone with relevant information who has not yet spoken to police to come forward.

The accused man remains before the courts, and the matter is subject to ongoing legal proceedings. As such, further public comment from authorities is expected to remain limited while the case progresses through the judicial system.